William G. Whitford
Originally developed for optimizing microbial
fermentation, the fed-batch approach has become a leading technology in biologics production based on animal cell culture. For manufacturing-scale
applications, we can simply address
the batch, fed-batch, and perfusion
operating modes (1). But as the
number of basic reactor types and
production modes/strategies grows,
absolute categorization and
terminology become more difficult.
That is especially true when
considering small scales and more
academic (research) approaches, in
which concepts such as “fed perfusion”
have been described (2). Such
references can be confusing to
beginners trying to make sense of
the basic approaches available.
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